Chloramine-T potenciate elastase-induced emphysema in guinea pigs
نویسندگان
چکیده
منابع مشابه
Role of neutrophil elastase in ozone-induced airway responses in guinea-pigs.
Ozone-induced airway hyperresponsiveness occurs concurrently with neutrophilic inflammation and epithelial injury in various species including humans. The mechanism of neutrophil-induced airway hyperresponsiveness, however, has not yet been fully clarified. Neutrophil elastase (NE) is a multipotent protease released from activated neutrophils, which may play a role in ozone-induced airway hyper...
متن کاملMatrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs.
STUDY OBJECTIVE To evaluate the effect of CP-471,474 (Pfizer Global Research and Development; Groton, CT), a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) in an experimental model of emphysema. DESIGN Randomized, double-blinded, controlled experiment. SETTING Biochemistry and morphology laboratories and animal research facility. METHODS Guinea pigs were exposed to cigarette...
متن کاملEmphysema in Guinea Pigs Attenuates Tobacco Smoke-Induced Matrix Metalloproteinases Inhibition
2003;123;1633-1641 Chest Elizabeth M. Kudlacz, Peter G. Mitchell and Annie Pardo Moisés Selman, José Cisneros-Lira, Miguel Gaxiola, Remedios Ramírez, * Emphysema in Guinea Pigs Attenuates Tobacco Smoke-Induced Matrix Metalloproteinases Inhibition http://chestjournal.chestpubs.org/content/123/5/1633.full.html services can be found online on the World Wide Web at: The online version of this artic...
متن کاملOral N-acetylcysteine attenuates elastase-induced pulmonary emphysema in rats.
STUDY OBJECTIVE To study the effect of the antioxidant N-acetylcysteine (NAC) in the development of elastase-induced emphysema in rats. MATERIALS AND METHODS Wistar rats (n = 72) were orotracheally instilled with 75 IU elastase or saline solution. Eighteen rats from each group received the antioxidant NAC from 2 days before induction of the lesion until they were killed 2, 8, and 28 days afte...
متن کاملNeutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
To address the role of neutrophil elastase in pulmonary emphysema, neutrophil elastase-deficient mice and wild-type littermate controls were exposed to long-term cigarette smoke. Compared to wild-type littermates, mice that were deficient in neutrophil elastase were significantly protected (59%) from the development of emphysema. Previously, we demonstrated complete protection from emphysema in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Ensho
سال: 1984
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.4.4_493